Article

DYRK1A role in microtubule-based axonal transport regulates the retrograde dynamics of APP vesicles in human neurons

2021-02-25

Abstract excerpt

In Alzheimer’s Disease (AD) the abnormal intracellular distribution of the amyloid precursor protein (APP) affects its processing and, consequently, the generation of Aβ. Axonal transport plays key roles in the neuronal distribution of APP. The dual-specificity-tyrosine phosphorylation-regulated-kinase-1A (DYRK1A) has been associated with AD onset since its overexpression was found in Down syndrome and sporadic AD...

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Literature Corpus work: d071515a-185d-5242-a84c-9c77750ac2c4
DOI: 10.1101/2021.02.25.432601

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