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Article

Dynein and dynactin components modulate neurodegeneration induced by excitotoxicity.

Journal of neurochemistry - 1 Jul 2012

Fujiwara Takeshi, Morimoto Koji, Kakita Akiyoshi, Takahashi Hitoshi

Abstract excerpt

Glutamate excitotoxicity causes neuronal dysfunction and degeneration. It is implicated in chronic disorders, including Alzheimer's disease, and in acute CNS insults such as ischemia. These disorders share prominent morphological features, including axon degeneration and cell body death. However, the molecular mechanism underlying excitotoxicity-induced neurodegeneration remains poorly understood. A key molecular...

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Identifiers

PMID: 22515507
DOI: 10.1111/j.1471-4159.2012.07746.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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