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Article

Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models.

Human molecular genetics - 1 Jun 2011

Khandelwal Preeti J, Herman Alexander M, Hoe Hyang-Sook, Rebeck G William, Moussa Charbel E-H

Abstract excerpt

Intraneuronal amyloid-β (Aβ) may contribute to extracellular plaque deposition, the characteristic pathology of Alzheimer's disease (AD). The E3-ubiquitin ligase parkin ubiquitinates intracellular proteins and induces mitophagy. We previously demonstrated that parkin reduces Aβ levels in lentivir...

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Identifiers

PMID: 21378096
DOI: 10.1093/hmg/ddr091
PMCID: PMC3090189

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21378096-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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