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Article

Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?

Pharmacogenomics - 1 Jul 2010

Ruaño Gualberto, Thompson Paul D, Kane John P, Pullinger Clive R, Windemuth Andreas, Seip Richard L, Kocherla Mohan, Holford Theodore R, Wu Alan H B

Abstract excerpt

AIM: Administered at maximal dosages, the most common statins--atorvastatin, simvastatin and rosuvastatin--lower low-density lipoprotein cholesterol (LDLC) by an average of 37-57% in patients with primary hypercholesterolemia. We hypothesized novel genetic underpinnings for variation in LDLC levels in the context of statin therapy. MATERIALS & METHODS: Genotyping of 384 SNPs in 202 volunteers from a lipid...

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Share to Acetyl-CoA Carboxylase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20602615
DOI: 10.2217/pgs.10.58
PMCID: PMC2921920

Genes

ACACB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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