Article
Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation.
Lipids in health and disease - 2 Oct 2024
Liu Chenxu, Chu Xinqiao, Biao Yaning, Jin Qiubai, Zhang Yufang, Gao Ya, Feng Shuo, Ma Jizheng, Zhang Yixin
Abstract excerpt
BACKGROUND: Abnormal lipid metabolism is linked to intervertebral disc degeneration (IVDD), sciatica, and low back pain (LBP), but it remains unclear whether targeted interventions can prevent these issues. This study investigated the causal effects of lipid-lowering drug use on IVDD, sciatica, and LBP development. METHODS: Single-nucleotide polymorphisms (SNPs) linked to total cholesterol (TC),...
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