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Article

Genetic factors affecting statin concentrations and subsequent myopathy: a HuGENet systematic review.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Nov 2014

Canestaro William J, Austin Melissa A, Thummel Kenneth E

Abstract excerpt

Statins, 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors, have proven efficacy in both lowering low-density-lipoprotein levels and preventing major coronary events, making them one of the most commonly prescribed drugs in the United States. Statins exhibit a class-wide side effect of muscle toxicity and weakness, which has led regulators to impose both dosage limitations and a recall. This review...

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Source

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Identifiers

PMID: 24810685
DOI: 10.1038/gim.2014.41
PMCID: PMC4676271

Genes

ABCB1
ABCG2
GATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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