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Article

Mechanisms of statin-induced myalgia assessed by physiogenomic associations.

Atherosclerosis - 1 Oct 2011

Ruaño Gualberto, Windemuth Andreas, Wu Alan H B, Kane John P, Malloy Mary J, Pullinger Clive R, Kocherla Mohan, Bogaard Kali, Gordon Bruce R, Holford Theodore R, Gupta Ankur, Seip Richard L, Thompson Paul D

Abstract excerpt

OBJECTIVE: We investigated genetic variants predictive of muscular side effects in patients treated with statins. We utilized a physiogenomic approach to prototype a multi-gene panel correlated with statin-induced myalgia. BACKGROUND: Statin-induced myalgia occurs in ∼10% of lipid clinic outpatients. Its clinical manifestation may depend in part upon gene variation from patient to patient. METHODS: We genotyped...

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Identifiers

PMID: 21868014
DOI: 10.1016/j.atherosclerosis.2011.07.007
PMCID: PMC3224998

Genes

COQ2
DMPK

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