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Article

Chloride channel-dependent copper acquisition of laccase in the basidiomycetous fungus Cryptococcus neoformans.

Science China. Life sciences - 1 Jan 2010

Zhu ChangWei, Jiang Nan, Xiao DongGuang, Pan Jiao, Zhu XuDong

Abstract excerpt

The CLC chloride channel gene CLC-A of the pathogen yeast Cryptococcus neoformans was previously reported to be critical for multicopper laccase activity and growth at an elevated pH. This study reports that copper homeostasis was impaired in the clc-a mutant. This was demonstrated by the substantial decrease of the intracellular quantity of copper under copper-limited growth as determined by flame atomic...

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Source

Identifiers

PMID: 20596964
DOI: 10.1007/s11427-010-0021-8

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Chloride channel-dependent copper acquisition of laccase in the basidiomycetous fungus Cryptococcus neoformans.PMID 20596964Read ↗

A CLC-type chloride channel gene is required for laccase activity and virulence in Cryptococcus neoformans.Semantic proximity Read ↗

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