Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1.

doi:10.1128/EC.4.1.202-208.2005

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Article

Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1.

Eukaryotic cell - 1 Jan 2005

Missall Tricia A, Moran Jason M, Corbett John A, Lodge Jennifer K

Abstract excerpt

Laccases are thought to be important to the virulence of many fungal pathogens by producing melanin, a presumed oxygen radical scavenger. A laccase in Cryptococcus neoformans has been shown to synthesize melanin and contributes to the virulence and the survival in macrophages of this fungal pathogen. One C. neoformans laccase gene, LAC1, previously called CNLAC1, has been extensively studied, and we describe a...

Topics

Animals
Blotting, Southern
Cell Survival
Cryptococcosis
Cryptococcus neoformans
DNA
Free Radicals
Green Fluorescent Proteins
Hydrogen Peroxide
Laccase
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanins

Mice

Models, Biological

Models, Genetic

Mutation

Nitric Oxide

Nitrogen

Source

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Identifiers

PMID: 15643075
DOI: 10.1128/EC.4.1.202-208.2005
PMCID: PMC544170

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