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Article

Copper-mediated reversal of defective laccase in a Deltavph1 avirulent mutant of Cryptococcus neoformans.

Molecular microbiology - 1 Feb 2003

Zhu Xudong, Gibbons Jack, Zhang Shirong, Williamson Peter R

Abstract excerpt

Previous studies have shown that a Deltavph1 Cryptococcus neoformans mutant defective in vesicular acidification lacked several important virulence factors including a copper-containing laccase and was avirulent in a mouse model. In the present studies, we characterized laccase transcription and protein production to obtain insights into the mechanism of the vph1 mutation in this pathogen. Although transcription...

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PMID: 12581355
DOI: 10.1046/j.1365-2958.2003.03340.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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