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Article

A CLC-type chloride channel gene is required for laccase activity and virulence in Cryptococcus neoformans.

Molecular microbiology - 1 Nov 2003

Zhu Xudong, Williamson Peter R

Abstract excerpt

Laccase is a major virulence factor required for infection caused by the human pathogenic yeast Cryptococcus neoformans. However, cellular processes involved in the regulation and expression of laccase remain largely unknown in C. neoformans. Here we report the identification of a chloride channel gene CLC-A which is essential for laccase activity in C. neoformans. CLC-A shares homology to CLC-type voltage-gated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14622414
DOI: 10.1046/j.1365-2958.2003.03752.x

Genes

CLC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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