Article
Cigarette smoke-induced changes to alveolar macrophage phenotype and function are improved by treatment with procysteine.
American journal of respiratory cell and molecular biology - 1 May 2011
Hodge Sandra, Matthews Geoffrey, Mukaro Violet, Ahern Jessica, Shivam Aruna, Hodge Greg, Holmes Mark, Jersmann Hubertus, Reynolds Paul N
Abstract excerpt
Defective efferocytosis may perpetuate inflammation in smokers with or without chronic obstructive pulmonary disease (COPD). Macrophages may phenotypically polarize to classically activated M1 (proinflammatory; regulation of antigen presentation) or alternatively activated M2 (poor antigen presen...
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