Article
Effects of corticosteroids on COPD lung macrophage phenotype and function.
Clinical science (London, England : 1979) - 17 Apr 2020
Higham Andrew, Scott Tom, Li Jian, Gaskell Rosemary, Dikwa Aisha Baba, Shah Rajesh, Montero-Fernandez M Angeles, Lea Simon, Singh Dave
Abstract excerpt
The numbers of macrophages are increased in the lungs of chronic obstructive pulmonary disease (COPD) patients. COPD lung macrophages have reduced ability to phagocytose microbes and efferocytose apoptotic cells. Inhaled corticosteroids (ICSs) are widely used anti-inflammatory drugs in COPD; however, their role beyond suppression of cytokine release has not been explored in COPD macrophages. We have examined the...
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