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Article

The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function.

The European respiratory journal - 1 Apr 2022

Skronska-Wasek Wioletta, Durlanik Sibel, Le Huy Quang, Schroeder Victoria, Kitt Kerstin, Garnett James Peter, Pflanz Stefan

Abstract excerpt

BACKGROUND: Elevated counts of alveolar macrophages and attenuated phagocytic capacity are associated with chronic obstructive pulmonary disease (COPD). Factors governing macrophage phagocytosis are poorly understood. In this study we aimed to compare the influence of airway epithelial cell secretions from individuals with COPD and without COPD (non-COPD) on macrophage phagocytic activity, and the role of...

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Identifiers

PMID: 34561292
DOI: 10.1183/13993003.02732-2020
PMCID: PMC8989056

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