Article
Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease.
Journal of translational medicine - 15 Mar 2018
Chen Yung-Che, Lin Meng-Chih, Lee Chih-Hung, Liu Shih-Feng, Wang Chin-Chou, Fang Wen-Feng, Chao Tung-Ying, Wu Chao-Chien, Wei Yu-Feng, Chang Huang-Chih, Tsen Chia-Cheng, Chen Hung-Chen
Abstract excerpt
BACKGROUND: Controversy exists in previous studies on macrophage M1/M2 polarization in chronic obstructive pulmonary disease (COPD). We hypothesized that formyl peptide receptor (FPR), a marker of efferocytosis and mediator of M1/M2 polarization, may be involved in the development of COPD. METHODS: We examined FPR 1/2/3 expressions of blood M1/M2a monocyte, neutrophil, natural killer (NK) cell, NK T cell, T...
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