Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure

15 Jun 2018

Abstract excerpt

Macrophage infiltration is common to both emphysema and atherosclerosis, and cigarette smoke down-regulates the macrophage cholesterol efflux transporter ATP binding cassette (ABC)A1. This decreased cholesterol efflux results in lipid-laden macrophages. We hypothesize that cigarette smoke adversely affects cholesterol transport via an ABCA1-dependent mechanism in macrophages, enhancing TLR4/myeloid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced Glycation End Products research
Share to Cholesterol and Lipid Metabolism
Share to Drug Transport and Resistance Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29906247
DOI: 10.1096/fj.201701381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposurePMID 29906247Read ↗

Participation of ABCA1 Transporter in Pathogenesis of Chronic Obstructive Pulmonary DiseaseSemantic proximity Read ↗

Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and – independent signaling pathways with relevance to inflammatory lung diseaseSemantic proximity Read ↗

Gene expression profiling of human alveolar macrophages of phenotypically normal smokers and nonsmokers reveals a previously unrecognized subset of genes modulated by cigarette smoking.Semantic proximity Read ↗

Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants.Semantic proximity Read ↗

Elevated MicroRNA-33 in Sarcoidosis and a Carbon Nanotube Model of Chronic Granulomatous DiseaseSemantic proximity Read ↗

The impact of cigarette smoke exposure, COPD, or asthma status on ABC transporter gene expression in human airway epithelial cellsSemantic proximity Read ↗

A Distinctive Alveolar Macrophage Activation State Induced by Cigarette SmokingSemantic proximity Read ↗

The impact of cigarette smoke exposure, and COPD or asthma status on ABC transporter gene expression in human airway epithelial cellsSemantic proximity Read ↗

Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice.Semantic proximity Read ↗

Cigarette Smoke Exposure and microRNA in Human Alveolar Macrophages: A Pilot StudySemantic proximity Read ↗

ANT1 Deficiency Impairs Macrophage Metabolism and Migration, Protecting Against Emphysema in Chronic Obstructive Pulmonary DiseaseSemantic proximity Read ↗

ATP-binding cassette (ABC) transporters in normal and pathological lungSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.