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Article

Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis.

American journal of respiratory cell and molecular biology - 1 Mar 2016

Venosa Alessandro, Malaviya Rama, Choi Hyejeong, Gow Andrew J, Laskin Jeffrey D, Laskin Debra L

Abstract excerpt

Nitrogen mustard (NM) is an alkylating agent known to cause extensive pulmonary injury progressing to fibrosis. This is accompanied by a persistent macrophage inflammatory response. In these studies, we characterized the phenotype of macrophages accumulating in the lung over time following NM exposure. Treatment of rats with NM (0.125 mg/kg, intratracheally) resulted in an increase in CD11b(+) macrophages in...

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Source

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Identifiers

PMID: 26273949
DOI: 10.1165/rcmb.2015-0120OC
PMCID: PMC4821033

Genes

CCL2
CCL5
CCR2
CCR5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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