Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Origin remodeling and opening in bacteria rely on distinct assembly states of the DnaA initiator.

The Journal of biological chemistry - 3 Sept 2010

Duderstadt Karl E, Mott Melissa L, Crisona Nancy J, Chuang Kevin, Yang Haw, Berger James M

Abstract excerpt

The initiation of DNA replication requires the melting of chromosomal origins to provide a template for replisomal polymerases. In bacteria, the DnaA initiator plays a key role in this process, forming a large nucleoprotein complex that opens DNA through a complex and poorly understood mechanism. Using structure-guided mutagenesis, biochemical, and genetic approaches, we establish an unexpected link between the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Bacterial
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Single-Stranded

Share to Escherichia coli

Share to Mutagenesis

Share to Protein Structure, Tertiary

Share to Protein Subunits

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 20595381
DOI: 10.1074/jbc.M110.147975
PMCID: PMC2934688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Origin remodeling and opening in bacteria rely on distinct assembly states of the DnaA initiator.PMID 20595381Read ↗

A common mechanism for the ATP-DnaA-dependent formation of open complexes at the replication origin.Semantic proximity Read ↗

Origin recognition is the predominant role for DnaA-ATP in initiation of chromosome replication.Semantic proximity Read ↗

Regulatory dynamics in the ternary DnaA complex for initiation of chromosomal replication in Escherichia coli.Semantic proximity Read ↗

A nucleotide-dependent oligomerization of the Escherichia coli replication initiator DnaA requires residue His136 for remodeling of the chromosomal origin.Semantic proximity Read ↗

A nucleotide switch in the Escherichia coli DnaA protein initiates chromosomal replication: evidnece from a mutant DnaA protein defective in regulatory ATP hydrolysis in vitro and in vivo.Semantic proximity Read ↗

AAA+ ATPases in the Initiation of DNA ReplicationSemantic proximity Read ↗

Replisome assembly at oriC, the replication origin of E. coli, reveals an explanation for initiation sites outside an origin.Semantic proximity Read ↗

Tetramerization and interdomain flexibility of the replication initiation controller YabA enables simultaneous binding to multiple partners.Semantic proximity Read ↗

Rapid turnover of DnaA at replication origin regions contributes to initiation control of DNA replication.Semantic proximity Read ↗

An essential tryptophan of Escherichia coli DnaA protein functions in oligomerization at the E. coli replication origin.Semantic proximity Read ↗

Bacterial origin recognition complexes direct assembly of higher-order DnaA oligomeric structures.Semantic proximity Read ↗

The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP DnaA-specific initiation complexes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.