Article
Bacterial origin recognition complexes direct assembly of higher-order DnaA oligomeric structures.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2009
Miller Diana T, Grimwade Julia E, Betteridge Thu, Rozgaja Tania, Torgue Julien J-C, Leonard Alan C
Abstract excerpt
Eukaryotic initiator proteins form origin recognition complexes (ORCs) that bind to replication origins during most of the cell cycle and direct assembly of prereplication complexes (pre-RCs) before the onset of S phase. In the eubacterium Escherichia coli, there is a temporally similar nucleoprotein complex comprising the initiator protein DnaA bound to three high-affinity recognition sites in the unique origin...
Topics
- Bacterial Proteins
- Base Sequence
- Binding Sites
- DNA-Binding Proteins
- Escherichia coli
- Molecular Sequence Data
- Mutation
- Origin Recognition Complex
- Protein Binding
- Protein Structure, Quaternary