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Article

DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.

The Journal of cell biology - 28 Jun 2010

Kohzaki Masaoki, Nishihara Kana, Hirota Kouji, Sonoda Eiichiro, Yoshimura Michio, Ekino Shigeo, Butler John E, Watanabe Masami, Halazonetis Thanos D, Takeda Shunichi

Abstract excerpt

The chicken DT40 B lymphocyte line diversifies its immunoglobulin (Ig) V genes through translesion DNA synthesis-dependent point mutations (Ig hypermutation) and homologous recombination (HR)-dependent Ig gene conversion. The error-prone biochemical characteristic of the A family DNA polymerases Polnu and Pol led us to explore the role of these polymerases in Ig gene diversification in DT40 cells. Disruption of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Somatic Hypermutation, Immunoglobulin

Source

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Identifiers

PMID: 20584917
DOI: 10.1083/jcb.200912012
PMCID: PMC2894443

Genes

POLN
POLQ
POLH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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