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Article

Immunoglobulin gene conversion or hypermutation: that's the question.

Sub-cellular biochemistry - 1 Jan 2006

Buerstedde Jean-Marie, Arakawa Hiroshi

Abstract excerpt

Chicken B cells develop their primary immunoglobulin (Ig) gene repertoire by pseudogene templated gene conversion within the bursa of Fabricius. The DT40 cell line is derived from bursal B cells and continues to diversify its rearranged Ig light chain in cell culture. Ig gene conversion of DT40 requires expression of the AID gene which was earlier shown to be needed for Ig hypermutation and switch recombination...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17623897
DOI: 10.1007/978-1-4020-4896-8_2

Genes

RAD51
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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