Article
Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination.
Molecular and cellular biology - 1 Feb 2005
Hatanaka Atsushi, Yamazoe Mitsuyoshi, Sale Julian E, Takata Minoru, Yamamoto Kazuhiko, Kitao Hiroyuki, Sonoda Eiichiro, Kikuchi Koji, Yonetani Yasukazu, Takeda Shunichi
Abstract excerpt
BRCA2 is a tumor suppressor gene that is linked to hereditary breast and ovarian cancer. Although the Brca2 protein participates in homologous DNA recombination (HR), its precise role remains unclear. From chicken DT40 cells, we generated BRCA2 gene-deficient cells which harbor a truncation at the 3' end of the BRC3 repeat (brca2tr). Comparison of the characteristics of brca2tr cells with those of other...
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