Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.

The Journal of biological chemistry - 25 Sept 2009

Kikuchi Koji, Abdel-Aziz H Ismail, Taniguchi Yoshihito, Yamazoe Mitsuyoshi, Takeda Shunichi, Hirota Kouji

Abstract excerpt

Bloom syndrome caused by inactivation of the Bloom DNA helicase (Blm) is characterized by increases in the level of sister chromatid exchange, homologous recombination (HR) associated with cross-over. It is therefore believed that Blm works as an anti-recombinase. Meanwhile, in Drosophila, DmBlm is required specifically to promote the synthesis-dependent strand anneal (SDSA), a type of HR not associating with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Exodeoxyribonucleases

Share to Gamma Rays

Share to Immunoglobulins

Share to RecQ Helicases

Share to Sister Chromatid Exchange

Source

Open in PubMed Open full text

Identifiers

PMID: 19661064
DOI: 10.1074/jbc.M109.029348
PMCID: PMC2785323

Genes

BLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences.PMID 19661064Read ↗

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.Semantic proximity Read ↗

Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.Semantic proximity Read ↗

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair.Semantic proximity Read ↗

Establishment of the DNA repair-defective mutants in DT40 cells.Semantic proximity Read ↗

Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered RegionSemantic proximity Read ↗

Depletion of the bloom syndrome helicase stimulates homology-dependent repair at double-strand breaks in human chromosomes.Semantic proximity Read ↗

Multiple functions of Drosophila BLM helicase in maintenance of genome stability.Semantic proximity Read ↗

Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability.Semantic proximity Read ↗

Intrachromosomal recombination between highly diverged DNA sequences is enabled in human cells deficient in Bloom helicase.Semantic proximity Read ↗

DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.Semantic proximity Read ↗

Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation.Semantic proximity Read ↗

Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.