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Article

Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Mar 2009

Arakawa Hiroshi, Buerstedde Jean-Marie

Abstract excerpt

Depending on the species and the developmental stage of B cells, activation-induced cytidine deaminase (AID) triggers immunoglobulin (Ig) gene diversification by gene conversion, hypermutation or switch recombination. The bursal B cell line DT40 usually diversifies its rearranged Ig light chain (IgL) gene by gene conversion, but disruption of the RAD51 gene paralogues or deletion of the psiV conversion donors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19008193
DOI: 10.1098/rstb.2008.0202
PMCID: PMC2660921

Genes

RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activation-induced cytidine deaminase-mediated hypermutation in the DT40 cell line.PMID 19008193Read ↗

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