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Article

Brca1 in immunoglobulin gene conversion and somatic hypermutation.

DNA repair - 1 Feb 2008

Longerich Simonne, Orelli Brian J, Martin Richard W, Bishop Douglas K, Storb Ursula

Abstract excerpt

Defects in Brca1 confer susceptibility to breast cancer and genomic instability indicative of aberrant repair of DNA breaks. Brca1 was previously implicated in the homologous recombination pathway via effects on the assembly of recombinase Rad51. Activation-induced cytidine deaminase (AID) deaminates C to U in B lymphocyte immunoglobulin (Ig) DNA to initiate programmed DNA breaks. Subsequent uracil-glycosylase...

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Source

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Identifiers

PMID: 18036997
DOI: 10.1016/j.dnarep.2007.10.002
PMCID: PMC2267027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Brca1 in immunoglobulin gene conversion and somatic hypermutation.PMID 18036997Read ↗

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Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID‐mediated deoxycytidine deaminationSemantic proximity Read ↗

Immunoglobulin gene conversion or hypermutation: that's the question.Semantic proximity Read ↗

Requirement of the activation-induced deaminase (AID) gene for immunoglobulin gene conversion.Semantic proximity Read ↗

Immunoglobulin Gene DiversificationSemantic proximity Read ↗

AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.Semantic proximity Read ↗

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