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Article

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation.

Nature - 30 Aug 2001

Sale J E, Calandrini D M, Takata M, Takeda S, Neuberger M S

Abstract excerpt

After gene rearrangement, immunoglobulin V genes are further diversified by either somatic hypermutation or gene conversion. Hypermutation (in man and mouse) occurs by the fixation of individual, non-templated nucleotide substitutions. Gene conversion (in chicken) is templated by a set of upstrea...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11528482
DOI: 10.1038/35091100

Genes

RAD51
XRCC2
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11528482-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation.PMID 11528482Read ↗

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Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID‐mediated deoxycytidine deaminationSemantic proximity Read ↗

Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination.Semantic proximity Read ↗

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