Article
Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations.
Cell cycle (Georgetown, Tex.) - 1 Jul 2010
Miller Emily S, Berman Seth D, Yuan Tina L, Lees Jacqueline A
Abstract excerpt
The E2F family of transcription factors, in association with pocket protein family members, are important for regulating genes required for cellular proliferation. The most abundant E2F, E2F4, is implicated in maintaining the G(0)/G(1) cell cycle state via transcriptional repression of genes that encode proteins required for S-phase progression. Here, we investigate E2F4's role in bone development using E2f4...
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