Article
The role of E2F4 in adipogenesis is independent of its cell cycle regulatory activity.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Landsberg Rebecca L, Sero Julia E, Danielian Paul S, Yuan Tina L, Lee Eunice Y, Lees Jacqueline A
Abstract excerpt
The E2F and pocket protein families are known to play an important role in the regulation of both cellular proliferation and terminal differentiation. In this study, we have used compound E2F and pocket protein mutant mouse embryonic fibroblasts to dissect the role of these proteins in adipogenesis. This analysis shows that loss of E2F4 allows cells to undergo spontaneous differentiation. The ability of E2F4 to...
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