Article
Recql4 haploinsufficiency in mice leads to defects in osteoblast progenitors: Implications for low bone mass phenotype.
Biochemical and biophysical research communications - 26 May 2006
Yang Jieping, Murthy Sreemala, Winata Therry, Werner Sean, Abe Masumi, Prahalad Agasanur K, Hock Janet M
Abstract excerpt
The cellular and molecular mechanisms that underlie skeletal abnormalities in defective Recql4-related syndromes are poorly understood. Our objective in this study was to explore the function of Recql4 in osteoblast biology both in vitro and in vivo. Immunohistochemistry on adult mouse bone showed Recql4 protein localization in active osteoblasts around growth plate, but not in fully differentiated osteocytes....
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