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Article

Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.

Molecular and cellular biology - 1 May 2003

Scheijen Blanca, Bronk Marieke, van der Meer Tiffany, Bernards René

Abstract excerpt

Longitudinal bone growth results from endochondral ossification, a process that requires proliferation and differentiation of chondrocytes. It has been shown that proper endochondral bone formation is critically dependent on the retinoblastoma family members p107 and p130. However, the precise functional roles played by individual E2F proteins remain poorly understood. Using both constitutive and conditional E2F1...

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Identifiers

PMID: 12724423
DOI: 10.1128/MCB.23.10.3656-3668.2003
PMCID: PMC164752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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