Article
Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation.
Nature genetics - 1 Apr 2000
Satokata I, Ma L, Ohshima H, Bei M, Woo I, Nishizawa K, Maeda T, Takano Y, Uchiyama M, Heaney S, Peters H, Tang Z, Maxson R, Maas R
Abstract excerpt
The composite structure of the mammalian skull, which forms predominantly via intramembranous ossification, requires precise pre- and post-natal growth regulation of individual calvarial elements. Disturbances of this process frequently cause severe clinical manifestations in humans. Enhanced DNA binding by a mutant MSX2 homeodomain results in a gain of function and produces craniosynostosis in humans. Here we...
Topics
- Abnormalities, Multiple
- Animals
- Bone Development
- Bone and Bones
- Cartilage
- Cell Differentiation
- Cell Division
- Cerebellum
- Chondrocytes
- DNA-Binding Proteins
- Ectodermal Dysplasia
- Hair Follicle
- Homeodomain Proteins