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Article

Novel functions for the transcription factor E2F4 in development and disease

18 Oct 2016

Abstract excerpt

The E2F family of transcription factors is a key determinant of cell proliferation in response to extra- and intra-cellular signals. Within this family, E2F4 is a transcriptional repressor whose activity is critical to engage and maintain cell cycle arrest in G0/G1 in conjunction with members of the retinoblastoma (RB) family. However, recent observations challenge this paradigm and indicate that E2F4 has a...

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PMID: 27753528
DOI: 10.1080/15384101.2016.1234551

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