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Article

Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner.

Cell stem cell - 8 Oct 2010

Kieslinger Matthias, Hiechinger Silvia, Dobreva Gergana, Consalez G Giacomo, Grosschedl Rudolf

Abstract excerpt

Hematopoiesis requires the interaction of hematopoietic stem cells (HSCs) with various stromal microenvironments. Here, we examine the role of early B cell factor 2 (Ebf2), a transcription factor expressed in a subset of immature osteoblastic cells. Ebf2(-/-) mice show decreased frequencies of HSCs and lineage-committed progenitors. This defect is cell nonautonomous, as shown by the fact that transplantation of...

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Identifiers

PMID: 20887955
DOI: 10.1016/j.stem.2010.07.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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