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Article

Critical Roles of E2F3 in Growth and Musculo-skeletal Phenotype in Mice.

International journal of medical sciences - 1 Jan 2019

Kim Hae-Rim, Rahman Faiz Ur, Kim Kwang-Soo, Kim Eun-Kyeung, Cho Sang-Mi, Lee Kihoon, Moon Ok-Sung, Seo Young-Won, Yoon Won-Kee, Won Young-Suk, Kang Hoyoung, Kim Hyoung-Chin, Nam Ki-Hoan

Abstract excerpt

E2F3, a member of the E2F family, plays a critical role in cell cycle and proliferation by targeting downstream, retinoblastoma (RB) a tumor suppressor family protein. The purpose of this study, was to investigate the role and function of E2F3 in vivo. We examined phenotypic abnormalities, by deletion of the E2f3 gene in mice. Complete ablation of the E2F3 was fully penetrant, in the pure C57BL/6N background. The...

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Identifiers

PMID: 31839743
DOI: 10.7150/ijms.39068
PMCID: PMC6909802

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