Article
Association of interleukin 4 -589T/C polymorphism with T(H)1 and T(H)2 bias and sepsis in Chinese major trauma patients.
The Journal of trauma - 1 Dec 2011
Gu Wei, Zeng Ling, Zhang Lian-Yang, Jiang Dong-Po, Du Ding-Yuan, Hu Ping, Wang Hai-Yan, Liu Qing, Huang Shu-Na, Jiang Jian-Xin
Abstract excerpt
BACKGROUND: Interleukin (IL)-4 is a pleiotropic cytokine, severed as an important component of the adaptive immune system, and implicated in the pathophysiology of sepsis. Data from other studies show that the -589T/C polymorphism in IL-4 promoter may alter IL-4 expression and susceptibility of i...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Asian People
- Chi-Square Distribution
- Cohort Studies
- Confidence Intervals
- Cytokines
- Disease Susceptibility
- Female
- Follow-Up Studies
- Humans
- Incidence
- Injury Severity Score