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Article

Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population.

Critical care (London, England) - 1 Jan 2011

Song Zhenju, Yin Jun, Yao Chenling, Sun Zhan, Shao Mian, Zhang Yaping, Tao Zhengang, Huang Peizhi, Tong Chaoyang

Abstract excerpt

INTRODUCTION: Deregulated or excessive host immune responses contribute to the pathogenesis of sepsis. Toll-like receptor (TLR) signaling pathways and their negative regulators play a pivotal role in the modulation of host immune responses and the development of sepsis. The objective of this study was to investigate the association of variants in the TLR signaling pathway genes and their negative regulator genes...

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Source

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Identifiers

PMID: 21219635
DOI: 10.1186/cc9413
PMCID: PMC3222042

Genes

TOLLIP
TNF
TLR2
TLR4
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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