Article
Identification and validation of genes affecting aortic lesions in mice.
The Journal of clinical investigation - 1 Jul 2010
Yang Xia, Peterson Larry, Thieringer Rolf, Deignan Joshua L, Wang Xuping, Zhu Jun, Wang Susanna, Zhong Hua, Stepaniants Serguei, Beaulaurier John, Wang I-Ming, Rosa Ray, Cumiskey Anne-Marie, Luo Jane Ming-Juan, Luo Qi, Shah Kashmira, Xiao Jianying, Nickle David, Plump Andrew, Schadt Eric E, Lusis Aldons J, Lum Pek Yee
Abstract excerpt
Atherosclerosis represents the most significant risk factor for coronary artery disease (CAD), the leading cause of death in developed countries. To better understand the pathogenesis of atherosclerosis, we applied a likeli-hood-based model selection method to infer gene-disease causality relationships for the aortic lesion trait in a segregating mouse population demonstrating a spectrum of susceptibility to...
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