Article
Applications and Limitations of Mouse Models for Understanding Human Atherosclerosis.
Cell metabolism - 7 Feb 2017
von Scheidt Moritz, Zhao Yuqi, Kurt Zeyneb, Pan Calvin, Zeng Lingyao, Yang Xia, Schunkert Heribert, Lusis Aldons J
Abstract excerpt
Most of the biological understanding of mechanisms underlying coronary artery disease (CAD) derives from studies of mouse models. The identification of multiple CAD loci and strong candidate genes in large human genome-wide association studies (GWASs) presented an opportunity to examine the relevance of mouse models for the human disease. We comprehensively reviewed the mouse literature, including 827...
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