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Article

Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data.

Circulation research - 3 Aug 2007

Wang Susanna S, Schadt Eric E, Wang Hui, Wang Xuping, Ingram-Drake Leslie, Shi Weibin, Drake Thomas A, Lusis Aldons J

Abstract excerpt

We report a combined genetic and genomic analysis of atherosclerosis in a cross between the strains C3H/HeJ and C57BL/6J on a hyperlipidemic apolipoprotein E-null background. We incorporated sex and sex-by-genotype interactions into our model selection procedure to identify 10 quantitative trait loci for lesion size, revealing a level of complexity greater than previously thought. Of the known risk factors for...

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PMID: 17641228
DOI: 10.1161/CIRCRESAHA.107.152975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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