Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype.

doi:10.1161/ATVBAHA.115.306958

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Article

Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016

Pasterkamp Gerard, van der Laan Sander W, Haitjema Saskia, Foroughi Asl Hassan, Siemelink Marten A, Bezemer Tim, van Setten Jessica, Dichgans Martin, Malik Rainer, Worrall Bradford B, Schunkert Heribert, Samani Nilesh J, de Kleijn Dominique P V, Markus Hugh S, Hoefer Imo E, Michoel Tom, de Jager Saskia C A, Björkegren Johan L M, den Ruijter Hester M, Asselbergs Folkert W

Abstract excerpt

OBJECTIVE: The genetically modified mouse is the most commonly used animal model for studying the pathogenesis of atherosclerotic disease. We aimed to assess if mice atherosclerosis-related genes could be validated in human disease through examination of results from genome-wide association studies. APPROACH AND RESULTS: We performed a systematic review to identify atherosclerosis-causing genes in mice and...

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Identifiers

PMID: 27079880
DOI: 10.1161/ATVBAHA.115.306958

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