Article
A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse.
Genetics - 1 Apr 2002
Dansky Hayes M, Shu Pei, Donavan M, Montagno Jill, Nagle Deborah L, Smutko John S, Roy Natalie, Whiteing S, Barrios Judith, McBride T J, Smith Jonathan D, Duyk Geoffrey, Breslow Jan L, Moore Karen J
Abstract excerpt
Therapeutic intervention for atherosclerosis has predominantly concentrated on regulating cholesterol levels; however, these therapeutics are not efficacious for all patients, suggesting that other factors are involved. This study was initiated to identify mechanisms that regulate atherosclerosis predisposition in mice other than cholesterol level regulation. To do so we performed quantitative trait locus...
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