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Article

NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.

Journal of cell science - 15 Jul 2010

Cha Boyoung, Zhu Xinjun Cindy, Chen Weiping, Jones Michelle, Ryoo Sungwoo, Zachos Nicholas C, Chen Tien-E, Lin Rong, Sarker Rafiquel, Kenworthy Anne K, Tse Ming, Kovbasnjuk Olga, Donowitz Mark

Abstract excerpt

The epithelial brush border (BB) Na(+)/H(+) exchanger NHE3 is associated with the actin cytoskeleton by binding both directly and indirectly to ezrin; indirect binding is via attachment to NHERF family proteins. NHE3 mobility in polarized epithelial cell BBs is restricted by the actin cytoskeleton and NHERF binding such that only approximately 30% of NHE3 in the apical domain of an OK cell line stably expressing...

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Source

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Identifiers

PMID: 20571054
DOI: 10.1242/jcs.056713
PMCID: PMC2936692

Genes

LPA
NHERF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.PMID 20571054Read ↗

Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.Semantic proximity Read ↗

Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP, and lysophosphatidic acid.Semantic proximity Read ↗

NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.Semantic proximity Read ↗

Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation.Semantic proximity Read ↗

NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions.Semantic proximity Read ↗

Regulation of epithelial apical junctions and barrier function by Galpha13.Semantic proximity Read ↗

cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein.Semantic proximity Read ↗

Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model.Semantic proximity Read ↗

Interferon-gamma inhibits enterocyte migration by reversibly displacing connexin43 from lipid rafts.Semantic proximity Read ↗

Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3.Semantic proximity Read ↗

Separate C-terminal domains of the epithelial specific brush border Na+/H+ exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors.Semantic proximity Read ↗

Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.Semantic proximity Read ↗

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