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Article

Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation.

The Journal of biological chemistry - 14 Jan 2005

Shiue Harn, Musch Mark W, Wang Yingmin, Chang Eugene B, Turner Jerrold R

Abstract excerpt

Initiation of Na(+)-glucose cotransport in intestinal absorptive epithelia causes NHE3 to be translocated to the apical plasma membrane, leading to cytoplasmic alkalinization. We reported recently that this NHE3 translocation requires ezrin phosphorylation. However, the kinase that phosphorylates ezrin in this process has not been identified. Because Akt has also been implicated in NHE3 translocation, we...

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Identifiers

PMID: 15531580
DOI: 10.1074/jbc.M409471200
PMCID: PMC1237052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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