NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.

doi:10.1152/ajprenal.00182.2009

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Article

NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.

American journal of physiology. Renal physiology - 1 Mar 2010

Dynia Diane W, Steinmetz Amy G, Kocinsky Hetal S

Abstract excerpt

Na+/H+ exchanger 3 (NHE3) is phosphorylated and regulated by multiple kinases, including PKA, SGK1, and CK2; however, the role of phosphatases in the dephosphorylation and regulation of NHE3 remains unknown. The purpose of this study was to determine whether serine/threonine phosphatases alter NHE3 activity and phosphorylation and, if so, at which sites. To this end, we first examined the effects of calyculin A...

Topics

Animals
Blotting, Western
COS Cells
Chlorocebus aethiops
Electrophoretic Mobility Shift Assay
Enzyme Inhibitors
Humans
Kidney Tubules, Proximal
Kinetics
Male
Marine Toxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microvilli

Mutation

Nuclear Proteins

Okadaic Acid

Opossums

Oxazoles

Phosphoprotein Phosphatases

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Open in PubMed Open full text

Identifiers

PMID: 20015946
DOI: 10.1152/ajprenal.00182.2009
PMCID: PMC2838583

Genes

SGK1

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