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Article

NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.

American journal of physiology. Renal physiology - 1 Mar 2010

Dynia Diane W, Steinmetz Amy G, Kocinsky Hetal S

Abstract excerpt

Na+/H+ exchanger 3 (NHE3) is phosphorylated and regulated by multiple kinases, including PKA, SGK1, and CK2; however, the role of phosphatases in the dephosphorylation and regulation of NHE3 remains unknown. The purpose of this study was to determine whether serine/threonine phosphatases alter NHE3 activity and phosphorylation and, if so, at which sites. To this end, we first examined the effects of calyculin A...

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Source

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Identifiers

PMID: 20015946
DOI: 10.1152/ajprenal.00182.2009
PMCID: PMC2838583

Genes

SGK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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