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Article

Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3.

The Journal of clinical investigation - 1 Dec 2004

Li Shaoying, Sato Soichiro, Yang Xiaojing, Preisig Patricia A, Alpern Robert J

Abstract excerpt

The present study examines the role of Pyk2 in acid regulation of sodium/hydrogen exchanger 3 (NHE3) activity in OKP cells, a kidney proximal tubule epithelial cell line. Incubation of OKP cells in acid media caused a transient increase in Pyk2 phosphorylation that peaked at 30 seconds and increa...

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Identifiers

PMID: 15599403
DOI: 10.1172/JCI18046
PMCID: PMC535061

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15599403-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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