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Article

Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.

The Journal of biological chemistry - 17 Jul 2009

Zachos Nicholas C, van Rossum Damian B, Li Xuhang, Caraveo Gabriela, Sarker Rafiquel, Cha Boyoung, Mohan Sachin, Desiderio Stephen, Patterson Randen L, Donowitz Mark

Abstract excerpt

Multiple studies suggest that phospholipase C-gamma (PLC-gamma) contributes to regulation of sodium/hydrogen exchanger 3 (NHE3) in the small intestine, although the mechanism(s) for this regulation remain unknown. We demonstrate here that PLC-gamma binds directly to the C terminus of NHE3 and exists in similar sized multiprotein complexes as NHE3. This binding is dynamic and decreases with elevated [Ca(2+)](i)....

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Identifiers

PMID: 19473983
DOI: 10.1074/jbc.M109.006098
PMCID: PMC2740569

Genes

NHERF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.PMID 19473983Read ↗

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