Article
NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions.
Biochemical and biophysical research communications - 25 Aug 2006
Favia M, Fanelli T, Bagorda A, Di Sole F, Reshkin S J, Suh P G, Guerra L, Casavola V
Abstract excerpt
It has been shown that when CFTR and NHE3 are co-expressed on the apical membrane of the A6-NHE3 cell monolayers, the two transporters interact via a shared regulatory complex composed of NHERF2, ezrin, and PKA. We observe here that co-expression of NHE3 reduced both PKA-dependent apical CFTR expression and its activation once in place by approximately 50%. To analyze the role of NHERF2 in this process, we...
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