Article
Separate C-terminal domains of the epithelial specific brush border Na+/H+ exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors.
The Journal of biological chemistry - 9 Jun 1995
Levine S A, Nath S K, Yun C H, Yip J W, Montrose M, Donowitz M, Tse C M
Abstract excerpt
NHE3, a cloned intestinal and renal brush border Na+/H+ exchanger, has previously been shown to be both stimulated and inhibited by different protein kinases/growth factors. For instance, NHE3 is stimulated by serum and fibroblast growth factor (FGF) and inhibited by protein kinase C. In the present study, we used a series of NHE3 C terminus truncation mutants to identify separate regions of the C-terminal...
Topics
- Base Sequence
- Calmodulin
- Epithelium
- Fibroblast Growth Factors
- Growth Substances
- Microvilli
- Molecular Sequence Data
- Mutation
- Protein Kinases
- Second Messenger Systems