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Article

Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.

American journal of physiology. Cell physiology - 1 Jul 2015

No Yi Ran, He Peijian, Yoo Byong Kwon, Yun C Chris

Abstract excerpt

Na(+)/H(+) exchange by Na(+)/H(+) exchanger 3 (NHE3) is a major route of sodium absorption in the intestine and kidney. We have shown previously that lysophosphatidic acid (LPA), a small phospholipid produced ubiquitously by all types of cells, stimulates NHE3 via LPA5 receptor. Stimulation of NHE3 activity by LPA involves LPA5 transactivating EGF receptor (EGFR) in the apical membrane. EGFR activates...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25855080
DOI: 10.1152/ajpcell.00067.2015
PMCID: PMC4490325

Genes

EGFR
LPA
PDK1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.PMID 25855080Read ↗

NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.Semantic proximity Read ↗

Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation.Semantic proximity Read ↗

Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca2+, cGMP, and lysophosphatidic acid.Semantic proximity Read ↗

Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4.Semantic proximity Read ↗

NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid.Semantic proximity Read ↗

Role of phosphatidic acid in the coupling of the ERK cascade.Semantic proximity Read ↗

Pyk2 activation is integral to acid stimulation of sodium/hydrogen exchanger 3.Semantic proximity Read ↗

A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1.Semantic proximity Read ↗

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Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity.Semantic proximity Read ↗

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