Article
Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model.
The Journal of biological chemistry - 14 Jun 2002
Bagorda Anna, Guerra Lorenzo, Di Sole Francesca, Hemle-Kolb Corinna, Cardone Rosa A, Fanelli Teresa, Reshkin Stephan J, Gisler Serge M, Murer Heini, Casavola Valeria
Abstract excerpt
Although Cystic fibrosis transmembrane conductance regulator (CFTR) has been shown to regulate the activity of NHE3, the potential reciprocal interaction of NHE3 to modulate the protein kinase A (PKA)-dependent regulation of CFTR in epithelial cells is still unknown. In the present work, we describe experiments to define the interactions between CFTR and NHE3 with the regulatory, scaffolding protein, NHERF that...
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